Hotel dei Marsi is easily reachable by the A25 High Way Roma-Pescara exiting at the Avezzano toll gate.
After paying the ticket, follow the main road going on the freeway direction SORA.
Go out when You'll see the signal of the industrial area (the signal is the only one that has black writing and yellow back ground), keep going and turn left at the round about.
We are just two minutes away.

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